What to Expect

Possible side effects

What are the possible side effects of INQOVI?

You may experience side effects while taking INQOVI. Your healthcare provider will take
blood tests before each cycle of INQOVI to help check the side effects such as cytopenias.

Record any side effects or important notes in your health journal, available in the INQOVI Treatment Kit or at INQOVI.com/healthjournal

The most common side effects of INQOVI include:

low white blood cell count (leukopenia)
low platelets in your blood (thrombocytopenia)
low white blood cell count (neutropenia)
low red blood cell count (anemia)
tiredness
constipation
bleeding
muscle pain

pain or sores in your mouth or throat
joint pain
nausea
shortness of breath
diarrhea
rash
dizziness
fever with low white blood cell count (febrile neutropenia)

swelling of arms or legs
headache
cough
decreased appetite
upper respiratory tract infection
pneumonia
changes in liver function tests

INQOVI may cause serious side effects, such as low blood cell counts. Low blood counts
are common with INQOVI but can also be serious and can lead to infections that may be
life-threatening. Your healthcare provider will check your blood counts regularly during
treatment with INQOVI. If you have low blood counts, your healthcare provider may need
to give you antibiotic medicines to prevent or treat infections or fever.

These are not all the possible side effects of INQOVI. Call your doctor for medical advice about side effects. You may report side effects to the Food and Drug Administration at
1‑800‑FDA‑1088

Tell your healthcare provider right away if you get any of the following signs
and symptoms of infection during treatment with INQOVI:

fever
chills
body aches
bruising more easily than usual

INQOVI may affect fertility in men. Talk to your healthcare provider if this is a concern
for you.

Tips for managing common side effects

Your healthcare provider may have ways to help manage certain side effects of INQOVI, such as adjusting or delaying your dosing cycle. The following information may also be helpful to you in managing some of the common side effects of INQOVI, along with your healthcare provider's care.

This information is not meant to replace your healthcare provider's advice. Always discuss any side effects with your healthcare provider.

Tiredness or weakness

Stress and anxiety may increase feelings of tiredness. You can try meditation or yoga to relax and release stress
Eat well and hydrate with about 8 cups of water or juice a day
Plan time to rest throughout the day, and consider taking short naps
Don't try to do too much. Ask for help with activities that require a lot of energy
Try to stay active with short walks or other low-effort exercise
Try to get at least 8 hours of sleep every night. Consider making a bedtime routine to relax before bed
Try keeping a diary of how you feel each day. You can share this with your healthcare provider or nurse to keep track of your energy levels
Talk to your healthcare provider. He or she may prescribe medication that can help decrease tiredness

Fever

You may have fever if you:
- Feel very warm or cold
- Have a headache or body aches
- Have shaking chills
- Have a skin rash or a new area of redness or swelling
- Have a new cough or shortness of breath
- Have a sore throat
- Have new belly pain
- Feel burning or pain while urinating
- Have pus coming from an injury or other location
- Feel confused or forgetful
Call your healthcare provider immediately if you have a fever or other signs of infection, such as chills, body aches, or bruising more easily than usual
To see if you have a fever, you can check your temperature by mouth. If you can't use this method, hold the thermometer under your armpit
- Your healthcare provider may tell you to contact them if your temperature reaches 100.5° F (38° C) or higher
A fever can cause fluid loss and dehydration. Drink plenty of liquids, like water, juice, and soup
Get enough rest
Keep cool by using a cold compress on your forehead
Your healthcare provider may prescribe medicine to help reduce fever. Do not take fever medicine without talking to your healthcare provider

Nausea or vomiting

You may feel nauseous on the days you take INQOVI tablets or shortly after
It may help to avoid certain foods. Try eating bland, easy-to-digest foods like crackers or toast instead of greasy, fried, sweet, or spicy foods
Avoid strong smells. Go outside and get a breath of fresh air if you feel like vomiting
Eat smaller meals throughout the day instead of 3 large ones. Eat food at room temperature
Talk to your healthcare provider, who may prescribe medicine to help reduce nausea. You can take this before treatment with INQOVI

Constipation

Talk to a healthcare provider if you have not had a bowel movement in 2 days
Keep a record of your bowel movements so that you can discuss with your healthcare provider what is normal for you
Talk to your healthcare provider about high-fiber foods you can eat. Some examples are bran muffins, cooked peas and beans, and peanut butter
Stay hydrated. Drink at least 8 cups of water or other fluids per day
Drink warm fluids like tea. Fruit juice such as prune juice may also help
Be active when you can. Ask your healthcare provider about ways to exercise while taking INQOVI

Diarrhea

Talk to your healthcare provider if:
- Your diarrhea lasts for more than 24 hours
- You experience pain along with diarrhea
- Your rectal area is sore or bleeds
Your healthcare provider may prescribe medication to help. Do not take medicine for diarrhea before talking to a doctor or nurse
Eat smaller meals throughout the day instead of 3 large ones
Ask your healthcare provider about foods high in sodium and potassium. Your body can lose these minerals when you have diarrhea and it's important to replace them
Eat low-fiber foods such as bananas, white rice, white toast, and plain or vanilla yogurt
Drink 8 to 12 cups of clear liquids each day, such as water or clear broth. Liquids containing electrolytes can be helpful
Drink liquids slowly and at room temperature

Cough

Cough can be caused by different things, such as:
- Allergies
- Secondhand smoke or chemicals
- Infection
- Acid reflux, or heartburn
Talk to your healthcare provider to determine the cause and type of cough. A cough can be acute (lasting less than 3 weeks) or persistent (more than 8 weeks)
Call your healthcare provider immediately if you cough up blood or colored mucus, or experience other symptoms with your cough
Avoid exposure to second hand smoke or chemicals that may irritate your throat. These can be found in hairspray or cleaning products
Avoid things you are allergic to. It's a good idea to vacuum and dust regularly if you have allergies
You can take a hot shower or use a humidifier to loosen mucus and moisten the throat
Stay hydrated to thin out the mucus in the throat
Talk to your healthcare provider about medicines that may help alleviate your cough, such as antihistamines or cough drops

Decreased appetite

Eat small meals throughout the day instead of 3 large ones
Set a daily schedule for meals, and eat even if you do not feel hungry
Drink liquid foods such as soup or smoothies if you do not feel like eating solid foods
Choose foods that are high in calories and/or protein
Use plastic forks or spoons if you get a metallic taste in your mouth
Being active may help you feel hungrier. Talk to your healthcare provider about exercises that can help
Talk to your healthcare provider, who may suggest that you take extra vitamins or supplements